赫克反应_Heck Reaction

在碱存在下，芳基卤化物或乙烯基卤化物与活化的烯烃之间的钯催化的CC偶联被称为“Heck反应”。催化剂和反应条件的最新发展导致更广泛的供体和受体适合于Heck反应。

Heck反应的一个好处是其出色的反式选择性。

Heck反应的机理

Recent Literature

Trifunctional N,N,O-terdentate amido/pyridyl carboxylate Pd(II) complexes were highly active and stable phosphine-free catalysts for Heck and room-temperature Suzuki reactions with high turnover numbers.
M. L. Kantam, P. Srinivas, J. Yadav, P. R. Likhar, S. Bhargava, J. Org. Chem., 2009, 74, 4882-4885.

New N-Heterocyclic Carbene Palladium Complex/Ionic Liquid Matrix Immobilized on Silica: Application as Recoverable Catalyst for the Heck Reaction
B. Karimi, D. Enders, Org. Lett., 2006, 8, 1237-1240.

Pd(quinoline-8-carboxylate)₂ as a Low-Priced, Phosphine-Free Catalyst for Heck and Suzuki Reactions
X. Cui, J. Li, Z.-P. Zhang, Y. Fu, L. Liu, Q.-X. Guo, J. Org. Chem., 2007, 72, 9342-9345.