阿布佐夫反应_Michaelis-Arbuzov反应_Arbuzov Reaction_Michaelis-Arbuzov Reaction
亚磷酸三烷基酯与卤代烷基反应生成膦酸烷基酯。第一步包括磷对卤代烷基的亲核攻击，随后卤离子对得到的三烷氧基鏻盐进行脱烷基。
该反应在制备用于Horner-Emmons反应的膦酸酯方面有着广泛的应用。
Arbuzov反应的机理
相关反应
霍纳-埃蒙斯反应
Kabachnik-Fields反应
膦酸酯的合成
Related Reactions
Horner-Emmons Reaction
Kabachnik-Fields Reaction
Synthesis of phosphonates
Recent Literature
Lewis Acid-Mediated Michaelis-Arbuzov Reaction at Room Temperature: A Facile Preparation of Arylmethyl/Heteroarylmethyl Phosphonates
G. G. Rajeshwaran, M. Nandakumar, R. Sureshbabu, A. K. Mohanakrishnan, Org. Lett., 2011, 13, 1270-1273.
Generation of Phosphoranes Derived from Phosphites. A New Class of Phosphorus Ylides Leading to High E Selectivity with Semi-stabilizing Groups in Wittig Olefinations
V. K. Aggarwal, J. R. Fulton, C. G. Sheldon, J. de Vicente, J. Am. Chem. Soc., 2003, 125, 6034-6035.
Reliable and Versatile Synthesis of 2-Aryl-Substituted Cinnamic Acid Esters
A. Ianni, S. R. Waldvogel, Synthesis, 2006, 2103-2112.