在强酸环境下醇和腈反应制备酰胺的反应。

Prins/Ritter串联反应。

参考文献

1. (a) Ritter, J. J.; Minieri, P. P. J. Am. Chem. Soc. 1948, 70, 4045-4048. (b) Ritter, J. J.; Kalish, J. J. Am. Chem. Soc. 1948, 70, 4048-4050.

2. Krimen, L. I.; Cota, D. J. Org. React. 1969, 17, 213–329. (Review).

3. Top, S.; Jaouen, G. J. Org. Chem. 1981, 46, 78-82.

4. Schumacher, D. P.; Murphy, B. L.; Clark, J. E.; Tahbaz, P.; Mann, T. A. J. Org. Chem.1989, 54, 2242-2244.

5. Le Goanvic, D; Lallemond, M.-C.; Tillequin, F.; Martens, T. Tetrahedron Lett. 2001,42, 5175-5176.

6. Tanaka, K.; Kobayashi, T.; Mori, H.; Katsumura, S. J. Org. Chem. 2004, 69,

5906-5925.

7. Nair, V.; Rajan, R.; Rath, N. P. Org. Lett. 2002, 4, 1575-1577.

8. Concellón, J. M.; Riego, E.; Suárez, J. R.; García-Granda, S.; Díaz, M. R. Org. Lett. 2004, 6, 4499-4501.

9. Brewer, A. R. E. Ritter reaction. In Name Reactions for Functional Group Transformations; Li, J. J., Ed.; Wiley: Hoboken, NJ, 2007, pp 471-476. (Review).

10. Baum, J. C.; Milne, J. E.; Murry, J. A.; Thiel, O. R. J. Org. Chem. 2009, 74,

2207-2209.

11. Yadav, J. S.; Reddy, Y. J.; Reddy, P. A. N.; Reddy, B. V. S. Org. Lett. 2013, 15, 546-549.

编译自：J.J. Li, Name Reactions: A Collection of Detailed Mechanisms and Synthetic Applications,  Ritter reaction，page 517-518.