α-二酮（或α-羟基酮，α-胺基酮，α-肟基酮）和甲酰氨缩合得到咪唑的反应。

反应机理

反应实例

4,5-Dimethylimidazole (3). A mixture of acetoin 1 (10 g, 0.116 mol) and formamide 2 (50 mL,66.7 g, 1.5 mol) was heated for 4 h, then distilled in vacuum and the portion with bp 165–175 ℃/11 mm was collected to afford 6 g of 3 (50%) as an oil which crystallized, mp 117 C, hydrochloride, mp 305 ℃.

【Bredereck H, Chem Ber., 1953, 6, 88】

【Bredereck H, Angew Chem., 1959, 71, 753】

【Journal of Heterocyclic Chemistry, 1981, 18, 23-25】

相关文献

1 Bredereck H Chem Ber 1953 6 88

2 Bredereck H Angew Chem 1959 71 753

3 Schubert H Zeitsch F Chem 1967 7 461

4 Novelli A Tet Lett 1967 265

5 Grimmett V Adv Heterocycl Chem 1970 12 113

6 Mothsra P Tet Lett 2006 47 5029

7 Hashemi MM Tet Lett 2008 49 2575

8 Lalitha A Tet Lett 2010 51 3018

编译自：Organic Syntheses Based On Name Reactions, 3RdEd, A. Hassner, Page 61-62.