喹啉或异喹啉在酰卤和氰基源存在下进行三组分缩合得到Reissert化合物，而后水解得到醛，喹啉羧酸和氨气的反应。

该反应中使改用N-氧化物的变体形式被称为Reissert-Henze反应。

反应机理

反应实例

不对称有机催化剂催化下Reissert化合物进行烯丙位烷基化反应。

参考文献

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编译自：Name Reactions （A Collection of Detailed Reaction Mechanisms）, Jie Jack Li, Reissert reaction，page 510-511.